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Might be unstable when exposed to air, light, or heat, reducing potency over time

For instance, transformation of human cells by the src oncogene of the Rous sarcoma virus results in constitutive phosphorylation of the receptor -subunit, but addition of IGF-1 further increases the level of phosphorylation (Werner and Le Roith, 2000)

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But as demand has grown, so has the question of how best to take it