These obesity medications, such as Glucagon Like Peptide-1 Receptor Agonists (GLP-1 RAs), have gained significant attention for their promising efficacy in achieving weight loss
Unlike semaglutide, which is a modified peptide requiring special absorption-enhancing formulations, orforglipron is a small-molecule, non-peptide compound, meaning it's more stable, easier to manufacture, and potentially more affordable
Asked specifically about the boxes labelled retatrutide circulating in Johannesburg gyms, she said: It is still under clinical investigation
Glucagon-like peptide-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR), is broadly expressed on the surfaces of various cells, including the pancreas, intestine and brain [8]
Because retatrutide is not currently approved in the UK, the final cancer warnings, contraindications and safety guidance will only be confirmed if the medicine is reviewed and licensed by regulators
Most patients require long-term or indefinite GLP-1 therapy to maintain benefits, as discontinuation typically results in weight regain and worsening metabolic parameters