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Signs of Dehydration or Electrolyte Imbalance Severe or persistent gastrointestinal side effects can lead to dehydration and potentially acute kidney injury

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For instance, semaglutide, a novel GLP-1RA, has demonstrated promise in ameliorating EAE-induced cognitive and physical dysfunction in mice

A 2022 post-hoc analysis of the SUSTAIN and PIONEER trial programs found that statin-treated participants achieved lipid reductions consistent with expected statin efficacy, with no signal of reduced LDL-lowering in the semaglutide arms compared to placebo [5]