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In addition, SURPASS-4 had the longest duration of the completed studies phase 3 studies tirzepatide trials (Table 1)

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Muscle mass declines as you age , especially from age 30

In ATTAIN-1, 3,127 overweight participants without diabetes were enrolled, while in ATTAIN-2, 1,613 overweight patients with type 2 diabetes were enrolled

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These findings are supported by multiple rodent studies showing enhanced biomechanical strength and collagen organization in repaired tendons