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The drug works by inhibiting an enzyme called dihydrofolate reductase (DHFR), which plays a key role in the metabolic pathways that produce glutathione, as well as the pathways that produce new DNA bases

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These differential genes were analyzed for GO and KEGG enrichment ( Figures 9B, C ), and GO was enriched in several biological processes, including DNA replication, regulation of signaling receptor activity, leukocyte chemotaxis and migration, etc

Used together, their combined effect on neuroinflammatory tone may be more comprehensive than either achieves alone, helping to slow the inflammatory processes that accelerate neurodegeneration during and after the menopausal transition

42: 28532863 (2020) Poplawski T, Chojnacki C, Czubatka A, Klupinska G, Chojnacki J, Blasiak J