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In terms of thyroid function, semaglutide has no established direct effect on the production or regulation of thyroid hormones such as thyroxine (T4) or triiodothyronine (T3)

Preclinical and clinical studies have uncovered several gastrointestinal effects of metformin, including stimulation of the incretin hormone glucagon-like peptide-1 (GLP-1) [8], slowing of gastric emptying [8], suppression of intestinal glucose absorption [9], inhibition of bile acid resorption [10, 11] and modulation of the gut microbiota [12]

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Yesburping typically resolves within 24 weeks as your digestive system adapts to delayed gastric emptying and you naturally eat smaller portions