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Results from a phase 2 study support that PXL065 improves liver fat content, procollagen III N-terminal propeptide, and NAFLD fibrosis score, as well as histological parameters, including NAS and fibrosis, with a favorable safety profile

L-cystine is reduced in the BBB, and the resulting cysteine is transported out of the endothelial cells into the brain via L-type amino acid transporter 1 (LAT1) (Snchez del Pino et al., 1995)

Tanning effect: PT-141 produces minimal tanning due to reduced MC1R activity

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Aliquots of 1 ml of the nanodispersion and 3 mL dichloromethane (DCM) were vortexed vigorously for 2 min at room temperature to obtain the free amount of carotenoid in dispersion