, a panel of experts will discuss the relative risks and strategies for mitigating the severe side effects of GLP-1 receptor agonists in the treatment of obesity
patients should be counseled to report symptoms such as neck mass, dysphagia, or persistent hoarseness Contraindication : Personal or family history of MTC or MEN2 Gallbladder disease : Tirzepatide may increase risk of gallstones and cholecystitis Acute kidney injury : Dehydration from gastrointestinal adverse effects may impair renal function Pancreatitis : Patients should be counseled to report severe, persistent abdominal pain Niacin-specific safety concerns: Hepatotoxicity : Baseline liver function tests and monitoring during dose titration and periodically thereafter are recommended
Longer-acting formulations with monthly dosing aim to reduce treatment burden and improve adherence
Haselkorn T, Fish JE, Chipps BE, Miller DP, Chen H, Weiss ST
Lancet 321, 12061209
In a healthy state, the body's antioxidant defenses neutralize these free radicals before they can cause harm
