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Summary: A hydroxocobalamin B12 injection typically maintains therapeutic levels for approximately 8 to 12 weeks in most patients, which is why maintenance injections are usually given every 2 to 3 months

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According to the FDA-approved prescribing information, gastrointestinal adverse reactions (nausea, vomiting, diarrhea) occur in up to 43% of patients taking Mounjaro and 37% of patients taking Zepbound, with higher rates during dose escalation phases

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Additionally, we noted the inhibition of cell death with Nec-1, suggesting that OGD has the potential to induce necroptosis, aligning with findings by Qi et al