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The lysosome as a cellular centre for signalling, metabolism and quality control

The data shows that by facilitating substantial weight loss and improving key markers like blood sugar, blood pressure, and cholesterol, these medications offer a powerful pathway for early intervention and long-term health benefits.

Alternatively, STING may be degraded through selective macroautophagy, whereby TBK1-mediated phosphorylation of p62 at S403 increases its affinity for K63-ubiquitinated STING (168) and ubiquitously expressed transcript (UXT) may facilitate the interaction between p62 and STING (169)