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How researchers categorize peptides studied for metabolic and adipose-related outcomes Researchers typically sort fat-metabolism peptides into three broad mechanism-based groups: lipolytic peptides studied for direct interaction with fat cell receptors, growth-hormone secretagogues studied for their downstream effects on metabolic rate, and incretin-pathway peptides studied for their roles in appetite and glucose regulation

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Notably, PPAR alone is not sufficient to restore redox homeostasis and promote the M2 phenotype, as demonstrated by the exacerbation of neuroinflammatory cytokine production in NRF2-deficient mice challenged with LPS (Innamorato et al., 2008)

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doi: 10.1016/j.phrs.2015.11.024 146 PoplawskiS