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Differences in continuous variables among diagnostic groups were analyzed using the KruskalWallis test with multiple comparisons adjusted with Bonferroni

Quality control of inductively coupled plasmatriple quadrupole mass spectrometer measurements was ensured through a combination of repeat measurements of: Acid blanks A quality control standard made from 1,000 mg l 1 High-Purity Standards multi-element standard solutions A tenfold dilution of the CRM-TMDW (trace metal drinking water) from High-Purity Standards Analyte measurements were normalized to the internal standard Iridium ( 193 Ir) to account for instrument drift and matrix effects, and measurements were subsequently blank corrected by removing the average analyte intensity of repeat blank measurements