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10.1007/978-3-7091-6346-7_64 Acta Neurochir

While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism

Hellenic J Cardiol

Less common systemic effects include mild lightheadedness (possibly copper-related), temporary headache, and occasional mild fatigue

L.LadrorD

Retrieved from: LAmoreaux, W