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In addition to SULT1A1 and 1A3/4, sulfation of APAP in the human fetal liver is carried out by SULT1E1 and SULT2A1 [29]

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The results indicated that metformin activated guanosine 5-triphosphate cyclohydrolase 1 (GTPCH1), leading to the recoupling of endothelial nitric oxide synthase (eNOS)