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doi: 10.1111/1753-0407.12883 5 WilcoxTDe BlockCSchwartzbardAZNewmanJD

However, skin benefits may gradually reduce over time if maintenance treatment and healthy habits are not followed

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Even when a small fraction does reach the viable epidermis, the molecule has a short functional half-life unless it is stabilized in the formulation (encapsulation, copper chelation, or both) 1