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Additionally, the substrate specificity may differ in the isoforms of each gene product, arising due to posttranscriptional (alternative splicing) or posttranslational modifications

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capsulatum , and while its exact function is yet to be elucidated, silencing of YPS3 results in reduced organ colonization in a murine model of infection [250]

COMT is involved in converting 2-hydroxyestradiol (an antiestrogen) to 2-methoxyestradiol (proestrogen), creating a hyper-estrogenic milieu due to the decrease in antiestrogen and an increase in proestrogen

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