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This article extensively outlines the GMs precise regulation of bone metabolic homeostasis, including intestinal barrier homeostasis control, immune homeostasis, the release of metabolic products (e.g., estrogen, IGF-1, and 5-HT signaling), the endocrine system, and the neural circuitry

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Break-induced replication Recombination-dependent DNA synthesis that initiates from a double-strand break and occurs following strand invasion mediated by RAD51 or RAD52