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Tirzepatide , marketed as Mounjaro and Zepbound, takes the mechanism a step further
Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)
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Their actions on brain insulin signaling, neuroinflammation, oxidative stress, and mitochondrial function likely contribute to improvements in motor and non-motor symptoms, including cognition, mood, and apathy, while maintaining a neutral effect on dyskinesias
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