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A 2026 retrospective study in The Lancet found that postmenopausal women receiving tirzepatide alongside hormone therapy were more than four times as likely to achieve 30% weight loss compared to those on tirzepatide alone: 18% versus 4%

This is consistent with previous studies reporting reduced alcohol craving after GLP-1RA semaglutide administration 22

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It works because of the sodium-glucose cotransport mechanism, which pulls water across the gut wall significantly faster than plain water can manage alone