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The product monograph indicates that patients aged 18 years and older should start on 1 mg daily, increasing by 0.5 mg daily every 2 weeks to a maximum of 3.0 mg daily, if tolerated
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Intestinal bacteria produce various bioactive metabolites, which can be absorbed into the enterohepatic circulation and enter the host blood circulation system, affecting host physiology directly or indirectly (7)
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