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This study was based on the hypothesis that cadherins mediate cell-to-cell adhesion and that they are essential for normal epithelial cell function and development

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However, the extent and speed of effects vary depending on individual factors like baseline B12 levels, metabolism, and overall health

Specifically, intra-articular injection or systemic administration of specific ferroptosis inhibitors such as ferrostatin-1, or pharmacologically for example, using natural products or genetically for example, using overexpression vectors upregulating GPX4 expression, activating SLC7A11, or the key transcription factor Nrf2, can, to varying degrees, restore cartilage morphology, reduce chondrocyte death, and significantly lower the expression levels of ECM degradation markers in OA animal models

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