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Molecules 26:1505 Braun W, Vak M, Robbins AH, Stout CD, Wagner G, Kgi JHR, Wthrich K (1992) Comparison of the NMR solution and the x-ray crystal structure of rat metallothionein-2

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Unlike the reversible albumin binding used by GLP-1 agonists, the DAC forms an irreversible bond with serum albumin, creating a circulating depot that extends the half-life of a GHRH analog from minutes to days