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Since the use of animal insulin for the treatment of diabetes in 1922, about nine major classes of drugs for the treatment of diabetes have been discovered and developed worldwide, including sulfonylureas, biguanides, -glucosidase inhibitors, insulins, thiazolidinediones (TZDs), meglitinides, GLP-1RAs, DPP-4 inhibitors, and SGLT-2 inhibitors

Its mechanisms are complex and heterogeneous, and it has become a core obstacle to limited clinical efficacy

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[1] [2] If a patient needs to change their injection day, the FDA label permits this as long as the new dose is administered at least 72 hours (three days) after the previous injection