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Structural figures were prepared using UCSF Chimera X and PyMOL v2.1 ( Data availability The atomic coordinates and the electron microscopy maps have been deposited in the Protein Data Bank (PDB) under the accession codes: 8WG7 (GLP-1RG s Nb35 complex), 8WG8 (GCGRG s Nb35 complex) and 8WA3 (GIPRG s Nb35 complex), and Electron Microscopy Data Bank (EMDB) with the accession codes: EMD-37504 (GLP-1RG s Nb35 complex), EMD-37505 (GCGRG s Nb35 complex) and EMD-37390 (GIPRG s Nb35 complex)

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