With its multiple benefits, including improved blood sugar control, significant weight loss, and reduced cardiovascular events, semaglutide is a versatile and effective option for many patients
Conversely, some case reports for exenatide 181 and semaglutide 182 described onset or relapse of depressive symptoms, which resolved when the GLP-1RAs were stopped 181,182 and recurred on medication rechallenge 181
The conversation around GLP-1s often focuses on rapid weight loss and celebrity endorsements
J Biol Chem 250:14221426 Riedel G (1996) Function of metabotropic glutamate receptors in learning and memory
Those with type 1 diabetes or insulin-dependent type 2 diabetes must consult their endocrinologist before fasting on GLP-1s, as fasting reduces calorie intake and can increase hypoglycemia risk without medication adjustment
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