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Mmt and Mtt protecting groups are more difficult to remove, and therefore it is more difficult to guarantee the complete removal of protecting groups during scale-up production

The FDA's 2020 draft guidance on insanitary conditions at compounding facilities described contamination events at multiple non-cGMP pharmacies and specifically highlighted risk to immunocompromised populations [4]

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In people with type 2 diabetes, this balance is disrupted, leading to persistently high glucose levels

This dependency is not limited to MYC-driven tumor cells but also occurs in various other cancer cell lines, including lymphomas, prostate cancer, osteosarcoma, renal cell carcinoma, colorectal cancer, and small cell lung cancer [84, 86,87,88,89,90].These tumor cells rely on glutamine for cell survival and growth when MYC is activated