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Some patients prefer evening injections because they may reduce nausea, though the overall efficacy is not affected by the time of day

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Individuals with seizure disorders or psychiatric conditions should exercise caution, as high ammonia levels may exacerbate these conditions

Consuming medication far below their standard dosing may result in insufficient drug levels to achieve meaningful blood sugar control and weight loss

This involves histamine release due to a direct action of the medication (not an IgE-mediated allergic reaction)

It is most suitable for people who have not been able to achieve significant weight loss through diet and exercise alone