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This consideration is especially pertinent for women experiencing hormonal fluctuations during perimenopause or menopause, as the introduction of a medication that affects appetite and weight can intensify existing mental health challenges

doi: 10.1186/s12876-020-01577-5 52 MacfarlaneS.MacfarlaneG

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Decreases in maternal body weight, food consumption, and motor activity were observed concurrent with the fetal findings, which confounds the interpretation of relevance of these malformations to the human risk assessment