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Statistical analysis Sample sizes for single-nucleus transcriptomics and DREADD experiments were determined based on prior experience with similar paradigms 12,13

pH/glutathione (GSH)-responsive nanoparticles, engineered with a tannic acid-Fe + framework encapsulating sodium persulfate (Na 22 S 22 O 8 ), selectively release Fe + and sulfate radicals (SO 4 - ) in the acidic, GSH-rich tumor microenvironment

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Toxins, unhealthy diets, nutrient-lacking diets, obesity, germs, and sedentary lifestyles all challenge the liver by using up precious glutathione

Livers from patients, who overdosed on acetaminophen, exhibit upregulation of ABCC1 and ABCC4 mRNAs and elevated protein levels of ABCB1, ABCG2, ABCC4 and ABCC5

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