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(3) hepatic ATP depletion despite unchanged rate of mitochondrial respiration, suggesting increased ATP consumption relative to production

10.1016/S0140-6736(15)00803-X [DOI] [PubMed] [Google Scholar] 110.Katsiki N, Athyros VG, Karagiannis A, Mikhailidis DP

The article frames downstream metabolic markers such as fasting glucose, HbA1c, fasting insulin and the lipid panel as the practical read on whether therapy is working