Excessive MMP activity can lead to the weakening of fibrous caps and increase the risk of plaque rupture in atherosclerotic lesions
d ) Preferred conformation of MeTRaQ-G during MD simulation (322 ns) with methyl group pointing into hydrophobic pocket
Moghaddam B, Adams B et al (1997)
Bonora E, Frias JP, Tinahones FJ, Van J, Malik RE, Yu Z, et al
Since GLP-1 receptors are present in the sinoatrial node (39) both a direct stimulation of GLP-1 receptors in the conducting system of the heart and an indirect effect mediated by the modulation of autonomic nervous system could explain a positive chronotropic effect of GLP-1R agonist
However, a deeper understanding of the complex nature of BBB and BCB together with the development of the new models and the improvement of the current barrier-modeling techniques indicates that they may become a very useful research tool for studying BBB and BCB in the future