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In short, hypothyroidism may indirectly predispose the gut to slower clearance of pathogens or fungi

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TNF- acts through several mechanisms, directly affecting neuronal function, reducing 5-HT synthesis, impairing gut barrier integrity, and promoting intestinal muscularis inflammation

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Females, younger adults, and people with conditions like chronic kidney disease or heart failure tended to report more GI symptoms

As there is no reliable early screening method, most patients are diagnosed only at stages III and IV (International Federation of Gynecology and Obstetrics staging) (7)