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The findings indicate that SLC7A11 is most prominently expressed in the brain, followed by the thyroid, stomach, appendix, bladder, and gallbladder, while demonstrating lower expression levels in the kidney, heart, and liver

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(2) the specific CI inhibitor IACS-010759 was recently reported to promote neurotoxicity, making this an unattractive agent for combination therapy in CRC given the neurotoxicity long-recognized with oxaliplatin treatment 51