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This dual mechanism reduces appetite signals in the brain, slows stomach emptying, improves insulin sensitivity, and increases feelings of fullness

SYNERGY-NASH: Tirzepatide and metabolic steatohepatitis (MASH) SYNERGY-NASH (Loomba et al., NEJM 2024, NEJMoa2401943, PMID 38856224) is a phase 2 trial in 190 patients with metabolic steatohepatitis (MASH) and biopsy-proven stage 2 or 3 fibrosis

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Timelines vary significantly from person to person based on individual factors, dosing, and lifestyle

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