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Renal function should be monitored, as severe gastrointestinal adverse effects can lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment

Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD (2001) Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

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Additionally, challenges such as poor tissue culture response, inefficient transformation methods, limited genomic resources, restricted field evaluation, insufficient synergy between traditional and genomic techniques, regulatory barriers, and market constraints further obstruct progress