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Mechanisms of GLP-1 in the regulation of -cell mass remain unclear, but may involve MAP kinase, PKC, and phosphatidylinositol-3 kinase

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Ex-4 treatment upregulates the expression of the proteins critical for mitochondrial biogenesis, including peroxisome proliferator-activated receptor- coactivator-1 (PGC-1), nuclear respiratory factor-1 (NRF-1), and transcription factor a, mitochondrial (Tfam)

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