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Each has its own set of pros and cons regarding safety and efficacy

The ability to measure oxidized and reduced forms of NADs and glutathiones from the same sample also minimizes effects of separate sample handling

Both platforms are legitimate

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doi: 10.1016/j.freeradbiomed.2015.03.022

So, a major portion of a dose of phenacetin would be rapidly metabolised to paracetamol, it seemed possible that phenacetin owed some of its antipyretic activity to its main metabolite, paracetamol, whereas its most troublesome side effect (methemoglobinemia) was due to another metabolite-phenetidine