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Caffeine was administered through gavage in 9 out of 11 of the studies [32,33,34, 36,37,38,39, 41, 42], orally in 1 out of 11 cases [35], and indirectly through cell culture treatment in 1 out of 11 works [40]

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In biochemical and cellular research systems, NAD+ has been investigated for its role in redox balance and as a substrate for NAD+-dependent enzymes

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Off J Am Coll Gastroenterol