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GLP-1s support overall cardiometabolic health and help reduce the risk of conditions like heart disease and sleep apnea before they develop, he explains

GLP-1 stimulation in the microbiome Human intestinal cells show Akkermansias effect on GLP-1 production Akkermansia secretes p9 protein which stimulates GLP-1 production Clostridium butyricum increases GLP-1* Dose-dependent increase of GLP-1 by Clostridium butyricum in a cell-based assay *Based on internal Pendulum R&D data Breakthrough clinical research Were continually pushing the boundaries in scientific research, and were excited to conduct a human clinical trial on GLP-1 and the gut microbiome

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Multiple sclerosis patients taking glucagon-like peptide-1 receptor (GLP-1) agonists: a single-institution retrospective cohort study of tolerability and weight loss

Enhanced Safety Profile: In clinical trials, Mounjaro has shown excellent results for both diabetes and weight loss without increasing the risk of major side effects beyond those commonly seen with other GLP-1 medications

Statistics were calculated using GraphPad Prism 8 (v.8.4.3 (686))