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886 The intestinal microbiota metabolite capsiate is negatively correlated with cartilage degeneration score in OA mice, and capsiate reduces ferroptosis dependent osteoarthritis both in vivo and in vitro, through activation of SLC2A1 and inhibition of HIF-1
Furthermore, as a result of their pleiotropic effect on multiple organ systems, these agents are emerging as potential therapy for metabolic dysfunction-associated steatotic liver disease, neurodegenerative conditions, and behavioral health disorders [5, 6]
PMCID: PMC8608955
Matthews, D
The most practical approach focuses on the broader metabolic networkdiet, tolerance, and consistencyrather than treating one antioxidant as a shortcut
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