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Maintenance duration considerations Clinical trial data demonstrates that tirzepatide efficacy persists for at least 72 weeks, the duration of the longest published trials

Appendix A: Pregnancy, Lactation, and Reproductive Potential Labeling Purpose of This Appendix This appendix summarizes how pregnancy, breastfeeding, and reproductive potential information should be interpreted in medication education materials

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When methionine intake suddenly increases (whether dietary or via injection), the transsulfuration pathway that converts homocysteine to cysteine and eventually glutathione becomes rate-limited by the availability of vitamin B6 (pyridoxal-5-phosphate) and folate (5-MTHF)

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