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While no DNMTs in the REBASE database have been experimentally confirmed to target TCCG and other above-mentioned motifs, a possible explanation for the introduction of new methylation patterns at these motifs can be attributed to the presence of uncharacterized or orphan DNMTs 29,58 or changes in the environmental conditions 59

J Clin Invest (1964) 43:24757.10.1172/JCI104909 198 FiorucciSMencarelliAPalladinoGCiprianiS

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