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Nevertheless, although the number of patients who had a TyG index value of 8.8 (non-insulin resistance) increased significantly in both the no/low CKD risk and CKD groups after 12 months of treatment ( Figures 3A, B ), when further stratification according to CKD severity was performed, a lower proportion of patients achieving a TyG value 8.8 was reported in the subgroup of very high CKD risk ( Figures 3CE )