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Importantly, the enzymatic activity of TETs is regulated by 2-oxoglutarate (2OG) as a cofactor and suppressed by metabolites such as 2-hydroxyglutarate (2HG) as a competitor of 2OG

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Meanwhile, Luciferase activity assays revealed no significant difference in GGCT promoter activity between Gln+ and Gln- groups, indicating that Gln does not directly regulate GGCT transcription (Fig

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