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Furthermore, significantly elevated branch-chain fatty acids (BCFA), which are metabolic products of protein breakdown have been hypothesized to induce epithelium inflammation ( These microbial alterations coincided with PTSD symptomatology, BBB dysfunction and hippocampal neuroinflammation, which was confirmed by increased proinflammatory cytokine levels IL-1 and IL-6 (Tanelian et al., 2023)

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regulation of ion and water homeostasis

Jin J, Richardson L, Sheller-Miller S, Zhong N, Menon R (2018) Oxidative stress induces p38MAPK-dependent senescence in the feto-maternal interface cells

Together, these case studies from Bologna and Marmara demonstrate proactive steps towards fostering urban resilience

Rise of spatial proteomics In the context of depression, spatial proteomics allows for the investigation of region-specific protein distribution patterns, providing insights into how molecular changes vary across neural circuits