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the synthesis of melatonin by macrophages/microglia increases its phagocytic ability and reduces the oxidative stress participating in the recovery phase of the inflammatory response ( Over the past decades, studies reported neuroinflammatory responses in a series of neurodegenerative and psychiatric disorders

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A number of underlying mechanisms have been proposed, including increased oxidative stress, disruption of normal hormonal and neurological signaling, impaired cellular and mitochondrial processes, formation of abnormal proteins, and DNA damage

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