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272 EBV-miR-BART1-5p directly targeted the 1 catalytic subunit of AMP-activated protein kinase (AMPK1) and consequently mediated the AMPK/mTOR/HIF-1 pathway, which promoted NPC cell anomalous aerobic glycolysis and angiogenesis, ultimately leading to uncontrolled growth of NPC

doi: 10.1016/j.cell.2005.05.016 88 ChenYYChuHMPanKTTengCHWangDLWangAHet al

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However, levels decline with age, illness, and environmental exposure

Iqbal K, Liu F, Gong C-X