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Dihexa produced significant neurite outgrowth at picomolar concentrations

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Appropriately prescribed hormone therapy has been shown to preserve bone density and reduce fracture risk

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Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

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J., Ghabril, M

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Table 1 includes preclinical studies of dual and triple use of GLP1 receptor co-agonists in T2DM and obesity [83]

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