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Tirzepatide (Zepbound, 15 mg weekly), SURMOUNT-1, 72 weeks: mean weight loss approximately 22.5%

Through these mechanisms, IGF-1 LR3 stimulates cellular anabolism, enhances glucose and amino acid uptake, increases protein synthesis, and inhibits protein degradation

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Data availability The RNA sequenceing data that support the findings of this study have been deposited at the NCBI GEO data repository under accession number GSE143164