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Astrocytes as main target of toxic encephalopathies Hyperammonaemia and hepatic encephalopathy Hepatic encephalopathy is a primary astrocytopathy caused by an increased level of blood ammonium

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We sought to confirm these interactions and found that NSD2 (E272A and K253E) and FBXO22 (K229E and E169K) variants at these surfaces exhibited reduced SCF FBXO22 -dependent NSD2 ubiquitination (Fig